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Acute Myeloid Leukemia
Researchers from University of Texas report on findings in acute myeloid leukemia
June 23rd, 2009
According to recent research published in the journal Cancer Research, "Kit is a membrane-bound tyrosine kinase and receptor for stem cell factor (SCF) with a crucial role in hematopoiesis. Mutations of KIT occur in almost half of patients with core-binding factor leukemias, in which they have been associated with worse outcome." "Development of new compounds targeting Kit may therefore hold promise for therapy. We investigated the activity and mechanism of action of APcK110, a novel Kit inhibitor, in the mastocytosis cell line HMC1.2 (KITV560G and KITD816V), acute myeloid leukemia (AML) tines OCIM2 and OCI/AML3 (both wild-type), and primary samples from patients...
Source: Cancer Weekly (2009-06-23)
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