Esophageal Cancer
Findings from D.W. Cescon and co-authors broaden understanding of esophageal cancer
Published in Cancer Weekly, June 23rd, 2009
According to recent research from Toronto, Canada, "This study aimed to evaluate the prognostic significance of two functional single nucleotide polymorphisms (SNP) in the p53 pathway (p53 Arg72Pro and MDM2 T309G) in patients with esophageal cancer, and to determine the importance of histologic subtype in the SNP-outcome relationships. A cohort of 371 patients with esophageal carcinoma enrolled in Boston, USA from 1999 to 2004 were genotyped for the p53 and MDM2 SNPs."
"Associations between genotypes and overall survival (OS; the primary outcome) and progression-free survival (PFS) were assessed using the Kaplan-Meier method. Cox proportional hazard models, adjusted for...
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Source: Cancer Weekly (2009-06-23)
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