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Apoptosis
Data from York University provide new insights into apoptosis
June 23rd, 2009
"Saleem A, Adhihetty PJ, Hood DA. Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle," scientists writing in the journal Physiological Genomics report. "Physiol Genomics 37: 58-66, 2009. First published December 23, 2008; doi: 10.1152/physiolgenomics.90346.2008. - p53 is a tumor suppressor protein that also plays a role in regulating aerobic metabolism. Since skeletal muscle is a major source of whole body aerobic respiration, it is important to delineate the effects of p53 on muscle metabolism. In p53 knockout (KO) mice, we observed diminished mitochondrial content in mixed muscle and lowered peroxisome proliferator-activated receptor-gamma...
Source: Cancer Weekly (2009-06-23)
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