Cancer Weekly
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Autosomal Dominant Polycystic Kidney
Studies in the area of autosomal dominant polycystic kidney reported from University of California
June 23rd, 2009
According to a study from the United States, "Control of apoptosis in autosomal dominant polycystic kidney disease (ADPKD) and in at least some cancers is likely regulated by the endogenous cyclin kinase inhibitor p21, levels of this protein being decreased in ADPKD and increased in many malignancies. The cyclin kinase inhibitor roscovitine has shown efficacy in treatment of murine PKD." "We asked how a single agent can be efficacious in both PKD and cancer. Renal tubular epithelial cells were incubated at diverse roscovitine concentrations; apoptosis and senescence were measured. Subsequently, levels of pro- and antiapoptotic proteins were evaluated. Renal tubular...
Source: Cancer Weekly (2009-06-23)
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