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Pancreatic Cancer

Findings from D. Zhao and co-authors provide new insights into pancreatic cancer

Published in Cancer Weekly, June 23rd, 2009

"Overexpression of cyclooxygenase-2 (COX-2) is implicated in cancer development. This study examined the functional relevance of genetic polymorphisms in the COX-2 promoter and evaluated their associations with susceptibility to pancreatic cancer," scientists in Beijing, People's Republic of China report.

"Genotypes and haplotypes of COX-2 -765G/C, -1195G/A, and -1290A/G were analyzed in 393 pancreatic cancer patients and 786 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed by logistic regression. The function of the -765G-- >C polymorphism was examined by a set of biochemical assays. The -1195AA or -765GC genotype carriers had a 1.34-fold...

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