Cancer Weekly
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Brain Cancer
Reports on brain cancer findings from S. Tejada and co-researchers provide new insights
June 23rd, 2009
"Increased protein synthesis is regulated, in part, by two eukaryotic translation initiation factors (eIFs): eIF4E and eIF2 alpha. One or both of these factors are often overexpressed in several types of cancer cells; however, no data are available at present regarding eIF4E and eIF2 alpha levels in brain tumors. in this study, we analyzed the expression, subcellular localization and phosphorylation states of eIF4E and eIF2 alpha in 64 brain tumors (26 meningiomas, 16 oligodendroglial tumors, and 22 astrocytomas) and investigated the correlation with the expression of MIB-1, p53, and cyclin D1 proteins as well," scientists writing in the Journal of Histochemistry & Cytochemistry...
Source: Cancer Weekly (2009-06-23)
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