Gastroenterology
New findings from University of Michigan, College of Pharmacy in the area of gastroenterology published
Published in Cancer Weekly, June 23rd, 2009
Current study results from the report, 'The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport,' have been published. "The aim of this study was to elucidate the intestinal epithelial cell efflux transport processes that are involved in the intestinal transport of the H(2) receptor antagonist nizatidine. The intestinal epithelial efflux transport mechanisms of nizatidine were investigated and characterized across Caco-2 cell monolayers, in the concentration range 0.05-10 mM in both apical-basolateral (AP-BL) and BL-AP directions, and the transport constants of P-glycoprotein (P-gp) efflux activity were...
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Source: Cancer Weekly (2009-06-23)
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