Cancer Weekly
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Cancer Vaccines
New findings in cancer vaccines described by J. Zeng and co-researchers
June 23rd, 2009
According to a study from Guangzhou, People's Republic of China, "The present study investigated an immunotherapeutic strategy for rearranged during transfection proto-oncogene (ret)associated carcinomas in a transgenic MT/ret 304/B6 mouse model in which spontaneous tumors develop due to overexpression of the ret gene. A Ret peptide vaccine comprising an extracellular fragment of Ret protein and Th1-polarized immunoregulator CpG oligonucleotide (1826) induced strong and specific cellular and Immoral immune responses in wildtype C57BL/6 mice, showing that the Ret peptide has a strong immunogenic potential as part of an antitumor vaccine." "In MT/ret 304/B6 mice, however,...
Source: Cancer Weekly (2009-06-23)
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