Cancer Weekly
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Acute Lymphoblastic Leukemia
New acute lymphoblastic leukemia findings from D.M. Lucas and co-researchers published
June 30th, 2009
According to recent research published in the journal Blood, "Therapeutic options for advanced B-cell acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL) are limited. Available treatments can also deplete T lymphocytes, leaving patients at risk of life-threatening infections." "In the National Cancer Institute cell line screen, the structurally unique natural product silvestrol produces an unusual pattern of cytotoxicity that suggests activity in leukemia and selectivity for B cells. We investigated silvestrol efficacy using primary human B-leukemia cells, established B-leukemia cell lines, and animal models. In CLL cells, silvestrol LC50...
Source: Cancer Weekly (2009-06-30)
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