Cancer Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Apoptosis
Study results from Kaohsiung Medical University update understanding of apoptosis
June 30th, 2009
"This study is the first to investigate the anticancer effect of dehydrocostuslactone [DHE (3aS, 6aR, 9aR, 9bS)-decahydro3,6,9-tris(methylene) azuleno[4,5-b]furan-2(3H)-one)], a medicinal plant-derived sesquiterpene lactone, on hepatocellular carcinoma. Our results showed that DHE inhibits the proliferation of HepG2 and PLC/PRF/5 cells by inducing apoptosis," scientists in Kaohsiung, Taiwan report. "DHE induces up-regulation of Bax and Bak, down-regulation of Bcl-2 and Bcl-XL, and nuclear relocation of the mitochondrial factors apoptosis-inducing factor (AIF) and endonuclease G ( Endo G). DHE triggered endoplasmic reticulum ( ER) stress, as indicated by changes in...
Source: Cancer Weekly (2009-06-30)
|
