Cancer Weekly
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Apoptosis
Study results from Medical College of Georgia, Medical College broaden understanding of apoptosis
June 30th, 2009
According to recent research from the United States, "Jiang M, Wang C, Huang S, Yang T, Dong Z. Cisplatin-induced apoptosis in p53-deficient renal cells via the intrinsic mitochondrial pathway. Am J Physiol Renal Physiol 296: F983-F993, 2009." "First published March 11, 2009; doi:10.1152/ajprenal.90579.2008.-Nephrotoxicity is the major limiting factor for the use of cisplatin in cancer therapy. Recent studies have demonstrated an important role for p53 in cisplatin-induced renal injury. Nevertheless, pharmacological and genetic blockade of p53 only provides partial renoprotective effects, suggesting the presence of p53-independent injury mechanisms. To understand the...
Source: Cancer Weekly (2009-06-30)
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