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Atrophy
Study results from University of Gothenburg, Sahlgrenska Academy in the area of atrophy published
June 30th, 2009
"Proliferative inflammatory atrophy (PIA) of prostate has been proposed as a precursor lesion of prostate cancer. The aim of the current study was to evaluate the expression of p53 protein in PIA lesions and to investigate the relationship between p53 staining and Ki-67, glutathione S-transferase-p (GSTP1) and cyclooxygenase-2 (COX-2) immunohistochemical expression," scientists in Gothenburg, Sweden report. "The results revealed that p53 nuclear immunostaining appeared in PIA lesions in 2.1 +/- 3.4% (mean +/- SD) of the basal and 0.9 +/- 2.3% of the luminal epithelial cells. Both these values were significantly higher than those in normal-appearing acini (p <0.0001)....
Source: Cancer Weekly (2009-06-30)
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