Breast Cancer
Reports from V. Varadi and colleagues advance knowledge in breast cancer
Published in Cancer Weekly, July 7th, 2009
According to recent research from Heidelberg, Germany, "Telomere dysfunction is a key mechanism in cancer development. The human telomerase reverse transcriptase (TERT) is the rate-limiting catalytic subunit of the telomerase enzyme, which is necessary for the maintenance of telomere DNA length, chromosomal stability, and cellular immortality In our attempt to identify functional polymorphisms in the TERT gene and their effect oil breast cancer risk, we sequenced the promoter of the gene and identified three single nucleotide polymorphisms (SNPs) with a frequency of at least 10%."
"One of these SNPs, rs2853669 (-244 T> C), has been shown to affect telomerase activity...
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Source: Cancer Weekly (2009-07-07)
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