Cancer Weekly
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Cancer Vaccines
Research from V. Francois and colleagues has provided new data on cancer vaccines
July 7th, 2009
"Melanoma patients were injected with various vaccines containing a MAGE-A3 peptide presented by HLA-DP4. Anti-MAGE-A3.DP4 T cells were not, detectable in the blood before vaccination, but their frequencies after vaccination ranged from 2 x 10(-6) to 2 x 10(-6) among the CD4(+) blood T lymphocytes of the patients," investigators in Brussels, Belgium report. "The CD4(+) blood T lymphocytes that stained ex vivo with HLA-DP4 tetramers folded with the MAGE-A3 peptide were selected by flow cytometry and amplified under clonal conditions. About 5% of the CD4(+) T-cell clones that recognized the MAGE-A3.DP4 antigen had a CD25(+) phenotype in the resting state. These CD25(+)...
Source: Cancer Weekly (2009-07-07)
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