Cancer Weekly
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Drug Resistance
Research from University of Texas, M.D. Anderson Cancer Center has provided new data on drug resistance
July 7th, 2009
Data detailed in 'Tie2-mediated multidrug resistance in malignant gliomas is associated with upregulation of ABC transporters' have been presented. According to recent research from the United States, "Resistance and relapse are still primary causes that result in poor effectiveness of chemotherapy in malignant gliomas. Therefore, development of new therapeutic strategies requires the identification of key molecular pathways regulating chemoresistance." "We previously found that abnormal high expression of the Tie2 receptor in gliomas was associated with tumor malignancy. Here, we studied the role of Tie2 activation in drug resistance by testing the cytotoxicity of...
Source: Cancer Weekly (2009-07-07)
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