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Acute Lymphoblastic Leukemia
Findings in acute lymphoblastic leukemia reported from J. Romangomez and co-researchers
July 7th, 2009
According to a study from Cordoba, Spain, " To identify microRNAs (miRNAs) epigenetically regulated in acute lymphoblastic leukemia (ALL). We first examined ALL-derived cell lines for the presence of abnormal levels of two different histone modifications (trimethylation of H3 lysine 4 [K4H3me3] and dimethylation of H3 lysine 9 [K9H3me2]) in the 5'UTR regions around CpG islands of 78 miRNAs by chromatin immunoprecipitation (ChIP)-on-ChIP analysis." "Methylation status (methylation-specific polymerase chain reaction [PCR]) and expression (quantitative PCR) of miRNAs showing a pattern of histone modifications linked to a closed chromatin structure were analyzed in a panel...
Source: Cancer Weekly (2009-07-07)
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