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Acute Lymphoblastic Leukemia
Study findings from Drexel University broaden understanding of acute lymphoblastic leukemia
July 7th, 2009
According to a study from the United States, "We describe the rate finding of a T-cell acute lymphoblastic leukemia (T-ALL) and a pretreatment bone marrow karyotype mosaic for four distinct cell lines in a 4-year-old boy. G-banding analysis of metaphase cells identified a hyperdiploid cell fine (52 chromosomes) trisomic for chromosomes 6, 9, 11, 13, 19, and 22." "Fluorescence in situ hybridization (FISH) analysis demonstrated that these hyperdiploid cells were missing all three copies of the CDKN2A locus (alias pl6/Ink4) at 9p21. FISH analysis of interphase nuclei identified two abnormal cell fines: the majority of cells with homozygous deletions of the CDKN2A locus and...
Source: Cancer Weekly (2009-07-07)
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