Cancer Weekly
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Acute Myeloid Leukemia
Study findings from A. Oke et al broaden understanding of acute myeloid leukemia
July 7th, 2009
"Aurora kinases play a critical role in regulating mitosis and cell division, and their overexpression has been implicated in the survival and proliferation of human cancer. In this study, we report the in vitro and in vivo activities of AZD1152, a compound that has selectivity for aurora B kinase, in acute myeloid leukemia (AML) cell lines, primary AML samples, and cord blood cells," scientists in London, the United Kingdom report. "AZD1152 exerted antiproliferative or cytotoxic effects in all cell lines studied, inhibited the phosphorylation of histone H3 (pHis H3) on Ser10 in a dose-dependent manner, and resulted in cells with > 4N DNA content. THP-1 cells treated...
Source: Cancer Weekly (2009-07-07)
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