Cancer Weekly
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Angiogenesis
New angiogenesis research from Fourth Military Medical University discussed
July 7th, 2009
According to recent research published in the journal Cancer Letters, "Previous studies demonstrated that CD147 molecule, highly expressed on the surface of various malignant tumor cells, significantly correlated with the malignancy of these cancers; however, the role of HAb18G/CD147 in endothelial cells has yet to be established. In this study, we found that the expression of HAb18G/CD147 was significantly upregulated in activated HUVECs." "The inhibition of HAb18G/CD147 expression by specific siRNA led to significantly decreased angiogenesis in vitro. Our data indicate that HAb18G/CD147 may regulate angiogenesis via several mechanisms including proliferation,...
Source: Cancer Weekly (2009-07-07)
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