Cancer Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Angiotensins
Research reports on angiotensins from C. Cousin and colleagues provide new insights
July 7th, 2009
"The (pro) renin receptor [(P) RR] is a 35-kDa transmembrane protein that plays a pivotal role in angiotensin tissue generation and in nonproteolytic prorenin activation. We detected a soluble form of (P) RR [s(P) RR; 28 kDa] in the conditioned medium of cultured cells," scientists in Paris, France report. "The aims of our study were to identify the protease responsible for the generation of s(P) RR, the site of shedding, and to establish the existence of circulating s(P) RR in plasma. We identified furin as the protease responsible for the shedding of endogenous (P) RR based on the following: LoVo colon carcinoma cells devoid of active furin synthesize full-length (P)...
Source: Cancer Weekly (2009-07-07)
|
