Cancer Gene Therapy

Research from J. Ma and co-authors in the area of cancer gene therapy published

Published in Cancer Weekly, July 21st, 2009

According to a study from Shanghai, People's Republic of China, "Replication-competent adenovirus (RCAd) constitutes an alternative in cancer therapy. For obtaining advanced RCAd generations with high oncolytic capability and a good safety profile, we constructed an E2F promoter-regulated RCAd carrying p16 gene, AdE2F-p16, in which the E1a gene was controlled by the E2F promoter."

"The experimental data showed that the E2F promoter endowed AdE2F-p16 with high specificity in cancer cells. While rarely replicating in normal cells, AdE2F-p16 could replicate in p16-deficient cancer cells, with 2,937- to 160,000-fold increased replicative capability in different cancer cell...

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Source: Cancer Weekly (2009-07-21)

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