DNA Research

Recent studies by L. Rey and co-authors add new data to DNA research findings

Published in Cancer Weekly, July 28th, 2009

"Human DNA polymerase eta (Pol eta) modulates susceptibility to skin cancer by promoting translesion DNA synthesis (TLS) past sunlight-induced cyclobutane pyrimidine dimers. Despite its well-established role in TLS synthesis, the role of Pol eta in maintaining genome stability in the absence of external DNA damage has not been well explored," researchers in Toulouse, France report.

"We show here that short hairpin RNA-mediated depletion of Pol eta from undamaged human cells affects cell cycle progression and the rate of cell proliferation and results in increased spontaneous chromosome breaks and common fragile site expression with the activation of ATM-mediated DNA...

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Source: Cancer Weekly (2009-07-28)

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