Life Sciences

Reports by M. Rivas and co-researchers describe recent advances in life sciences

Published in Cancer Weekly, July 28th, 2009

"G protein-coupled receptors (GPCRs) are involved in the pathophysiology of a wide range of diseases and constitute an attractive therapeutic target. In the thyroid gland, TSH receptor (TSHR), a member of the GPCR family, is a major regulator of thyroid differentiation and function," scientists in Madrid, Spain report.

"Alterations in TSHR activity are often involved in the development of pathologies such as thyroid cancer and thyroid enlargement (goiter). Here we show that DREAM (downstream regulatory element antagonist modulator) modulates TSHR activity through a direct protein-protein interaction that promotes coupling between the receptor and G alpha s. In...

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Source: Cancer Weekly (2009-07-28)

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