Life Sciences

Research on life sciences discussed by M. Lupien and co-researchers

Published in Cancer Weekly, July 28th, 2009

"Proper activation of transcriptional networks in complex organisms is central to the response to stimuli. We demonstrate that the selective activation of a subset of the estrogen receptor alpha (ER alpha) cistrome in MCF7 breast cancer cells provides specificity to the estradiol (E2) response," investigators in the United States report.

"ER alpha-specific enhancers that are subject to E2-induced coactivator-associated arginine methyltransferase 1 (CARM1) action are critical to E2-stimulated gene expression. This is true for both FoxA1-dependent and independent enhancers. In contrast, a subset of E2-suppressed genes are controlled by FoxA1-independent ER alpha binding...

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Source: Cancer Weekly (2009-07-28)

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