Breast Cancer

Studies from University of Texas update current data on breast cancer

Published in Cancer Weekly, August 4th, 2009

"The alpha 6 beta 4 integrin is overexpressed in the basal subtype of breast cancer and plays an important role in tumor cell motility and invasion. EGFR is also overexpressed in the basal subtype of breast cancer, and crosstalk between alpha 6 beta 4 integrin and EGFR appears to be important in tumor progression," investigators in the United States report.

"We evaluated the effects of alpha 6 beta 4 crosslinking on the distribution and function of EGFR in breast carcinoma cell line MDA-MB-231. Receptor distribution was evaluated by fluorescence microscopy and multispectral imaging flow cytometry, and ligand-mediated EGFR signaling was evaluated using Western blots and...

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Source: Cancer Weekly (2009-08-04)

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