Published in Cancer Weekly, August 4th, 2009
"Activation of this pathway occurs in solid tumors, including ovarian epithelial tumors, through mutation of the PI3K subunit genes or inactivation of the tumor suppressor, PTEN. Activation of this pathway would be predicted to be tumorigenic in granulosa cells. Expression of the 2 PI3K subunit genes, PIK3CA, which...
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