Cancer

New findings reported from S. Bittinger and co-authors describe advances in cancer

Published in Cancer Weekly, August 4th, 2009

"Granulosa cell tumors (GCT) are a unique subset of ovarian tumors which have a Molecular phenotype resembling that of follicle stimulating hormone (FSH)-stimulated pre-ovulatory granulosa cells. FSH acts via its receptor to stimulate signaling pathways including the phosphatidylinositol 3-kinase (PI3K)-AKT pathway," scientists in Clayton, Australia report.

"Activation of this pathway occurs in solid tumors, including ovarian epithelial tumors, through mutation of the PI3K subunit genes or inactivation of the tumor suppressor, PTEN. Activation of this pathway would be predicted to be tumorigenic in granulosa cells. Expression of the 2 PI3K subunit genes, PIK3CA, which...

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Source: Cancer Weekly (2009-08-04)

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