Chorio Cancer

Research reports on chorio cancer from S. Goldman and colleagues provide new insights

Published in Cancer Weekly, August 4th, 2009

According to recent research from Afula, Israel, "Although the MMP-2 promoter lacks a canonical progesterone response element (PRE), the hormone inhibits MMP-2 expression and is part of treatment protocols in gynecological invasive pathologies, including endometriosis and endometrial hyperplasia. This study aimed to explore the mechanism by which progesterone inhibits MMP-2 expression."

"The effect of progesterone on MMP-2 expression in the JAR human choriocarcinoma cell line was analyzed by gelatin zymography. MMP-2 transcript expression was studied using Northern blot and semi-quantitative RT-PCR. Rat promoter deletion analysis, electrophoretic mobility shift and...

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Source: Cancer Weekly (2009-08-04)

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