DNA Research

Study results from L. Ding et al provide new insights into DNA research

Published in Cancer Weekly, August 4th, 2009

"Camptothecin (CPT) reversibly binds and stabilizes cleavable complexes formed between DNA and topoisomerase I (Topl), thereby activating many downstream signaling pathways. Although several pathways induced by CPT have been elucidated, there are additional proteins that represent targets of CPT pharmacological mechanisms and remain uncharacterized," researchers in Shanghai, People's Republic of China report.

"Using two-dimensional electrophoresis analysis and matrix assisted laser desorption/ionization-time of flight (MALDI-TOF)-MS/MS identification, we investigated the hepatocellular carcinoma cell line SMMC-7721 for changes of protein expression following CPT...

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Source: Cancer Weekly (2009-08-04)

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