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Gastrointestinal Stromal Tumors

Data on gastrointestinal stromal tumors discussed by researchers at Leiden University

Published in Cancer Weekly, August 4th, 2009

According to recent research published in the journal Clinical Cancer Research, "Altered expression of cell cycle/apoptosis key regulators may promote tumor progression, reflect secondary genetic/epigenetic events, and impair the effectiveness of therapy. Their expression pattern might then identify gastrointestinal stromal tumor (GIST) patient subgroups with different response to imatinib and elucidate novel therapeutic targets."

"Immunohistochemical evaluation of expression of p53, p16, p21, CHK2, CCND1, BCL2, CDK4, and MDM12 was done on 353 histologically validated GIST patients enrolled into a European/Australasian phase III trial. TP53 was screened for...

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