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Gastrointestinal Stromal Tumors

Researchers from University of Louvain describe findings in gastrointestinal stromal tumors

Published in Cancer Weekly, August 4th, 2009

"Histone deacetylase inhibitors have emerged as potent anticancer compounds. Using a nude-mouse xenograft model, for the first time we evaluated the response of human gastrointestinal stromal tumors (GIST) carrying different oncogenic KIT mutations to panobinostat (LBH589), administered single or in combination with imatinib," scientists writing in the journal Clinical Cancer Research report.

"We grafted the human GIST882 cell line with KIT exon 13 mutation and two biopsies from patients radiologically progressing under imatinib showing KIT exon11 and KIT exon9 mutations, respectively. Our study included 4 groups: A (n = 9; control), B (n = 10; panobinostat 10...

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