Glioblastoma
Study data from Mayo Clinic update understanding of glioblastoma
Published in Cancer Weekly, August 4th, 2009
According to a study from the United States, "Temozolomide (TMZ)-based therapy is the standard of care for patients with glioblastoma multiforme (GBM), and resistance to this drug in GBM is modulated by the DNA repair protein O-6-methylguanine-DNA methyltransferase (MGMT). Expression of MGMT is silenced by promoter methylation in approximately half of GBM tumors, and clinical studies have shown that elevated MGMT protein levels or lack of MGMT promoter methylation is associated with TMZ resistance in some, but not all, GBM tumors."
"In this study, the relationship between MGMT protein expression and tumor response to TMZ was evaluated in four GBM xenograft lines that...
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Source: Cancer Weekly (2009-08-04)
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