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Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

Published in Cancer Weekly, August 4th, 2009

Scientists from The Medical College of Wisconsin in Milwaukee, Sangamo Biosciences, Inc., (NASDAQ:SGMO), Sigma-Aldrich Corporation (NASDAQ:SIAL), Open Monoclonal Technology, Inc. (OMT) and INSERM announced the creation of the first genetically modified mammals developed using zinc finger nuclease (ZFN) technology.

In a paper published in the July 24, 2009 issue of Science, researchers describe the novel application of ZFNs to generate rats with permanent, heritable gene mutations, paving the way for the development of novel genetically modified animal models of human disease. ZFN technology will make the generation of such animals faster and will create new...

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