Published in Cancer Weekly, August 4th, 2009
"Statins have a selective anti-cancer effect due to over-expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoAR) in cancer cells, but statins may also activate PKC. Thus, we hypothesized that simultaneous treatment with statin and PKC inhibitor might synergistically enhance their anti-tumor efficacies against HCCs. Hepatocellular carcinoma cell growth was assessed using MTS assays, apoptotic cell...
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