Hybridoma

Reports from University of Ljubljana describe recent advances in hybridoma

Published in Cancer Weekly, August 4th, 2009

According to a study from Ljubljana, Slovenia, "Late endocytic compartments, containing MHC class II molecules in antigen presenting cells, fuse to each other in order to deliver antigens to these molecules. We have shown previously that fusion of late endocytic compartments takes place also in hybridomas."

"Therefore, we investigate here whether the level of fused late endocytic compartments affects the immunostimulatory capacity of hybridomas obtained by the electrofusion of dendritic and tumor cells. The level of fused late endocytic compartments in a single hybridoma cell was assessed and samples of electrofused cells were then cocultured with autologous T cells,...

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Source: Cancer Weekly (2009-08-04)

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