Hypercalcemia

Findings in hypercalcemia reported from W.J. Mckinstry and co-researchers

Published in Cancer Weekly, August 4th, 2009

According to a study from Fitzroy, Australia, "Parathyroid hormone-related protein (PTHrP) plays a vital role in the embryonic development of the skeleton and other tissues. When it is produced in excess by cancers it can cause hypercalcemia, and its local production by breast cancer cells has been implicated in the pathogenesis of bone metastasis formation in that disease."

"Antibodies have been developed that neutralize the action of PTHrP through its receptor, parathyroid hormone receptor 1, without influencing parathyroid hormone action through the same receptor. Such neutralizing antibodies against PTHrP are therapeutically effective in animal models of the humoral...

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Source: Cancer Weekly (2009-08-04)

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