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Liver Cancer

Research on liver cancer detailed by scientists at Zhejiang University

Published in Cancer Weekly, August 4th, 2009

"Hepatocellular carcinoma (HCC) is the fifth most frequent neoplasm with more than 500000 new cases diagnosed yearly. Novel liver cancer biomarkers are needed," investigators in Hangzhou, People's Republic of China report.

"By tandem mass spectrometry we analyzed the secretomes of 12 individual paired samples of liver cancer and adjacent normal tissues and identified 1528 proteins with >2 unique peptide hits. The false discovery rate was 3.4%. Using spectral counting, we found 87 proteins in the HCC group and 86 proteins in the normal group that showed fivefold overexpression. These proteins provided a rich source of biomarker candidates. We presented a novel...

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