RNA Research

Scientists at Harvard University, Medical Department target RNA research

Published in Cancer Weekly, August 4th, 2009

"An alternative to therapeutic targeting of oncogenes is to perform ''synthetic lethality'' screens for genes that are essential only in the context of specific cancer-causing mutations. We used high-throughput RNA interference (RNAi) to identify synthetic lethal interactions in cancer cells harboring mutant KRAS, the most commonly mutated human oncogene," scientists in the United States report.

"We find that cells that are dependent on mutant KRAS exhibit sensitivity to suppression of the serine/threonine kinase STK33 irrespective of tissue origin, whereas STK33 is not required by KRAS-independent cells. STK33 promotes cancer cell viability in a kinase...

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Source: Cancer Weekly (2009-08-04)

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