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Testicular Cancer

Reports outline testicular cancer research from J. Ellinger and colleagues

Published in Cancer Weekly, August 4th, 2009

"DNA hypermethylation is a common cancer associated alteration. We analyzed methylation patterns of cell-free serum DNA in patients with testicular cancer," researchers in Bonn, Germany report.

"Hypermethylation at APC, GSTP1, PTGS2, p14(ARF), p16(INK) and PASSF1A was analyzed using real-time polymerase chain reaction following methylation sensitive restriction endonuclease treatment in 73 patients with testicular cancer and 35 healthy individuals. Hypermethylation was more common in patients with testicular cancer than in healthy individuals, including APC 57% and 6%, p16(INK) 53% and 17%, p14(ARF) 53% and 0%, RASSF1A 47% and 0%, PTGS2 45% and 0%, and GSTP1 25% and 0%,...

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