Bloom Syndrome
Research from University of Paris yields new data on Bloom syndrome
Published in Cancer Weekly, August 4th, 2009
According to recent research from Villejuif, France, "Loss-of-function of caretaker genes characterizes a group of cancer predisposition diseases that feature cellular hypersensitivity to DNA damage and chromosome fragility; this group includes Fanconi anaemia and Bloom syndrome(1-3). The products of the 13 FANC genes(4) (mutated in Fanconi anaemia), which constitute the 'FANC' pathway, and BLM (the RecQ helicase mutated in Bloom syndrome) are thought to collaborate during the S phase of the cell cycle, preventing chromosome instability."
"Recently, BLM has been implicated in the completion of sister chromatid separation during mitosis, a complex process in which...
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Source: Cancer Weekly (2009-08-04)
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