Life Sciences
Research on life sciences detailed by J. Sun and co-authors
Published in Cancer Weekly, August 4th, 2009
Research findings, 'Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells,' are discussed in a new report. "We examined the effect of apogossypolone (ApoG2), a new derivative from gossypol on cell cycle regulation in U937 human leukemic monocyte lymphoma cells in vitro. ApoG2 decreased the viability of U937 cells by inducing G1 arrest followed by apoptosis in a dose-dependent manner," researchers in Guangzhou, People's Republic of China report.
"The G0/G1 phase of the cell cycle is regulated by cyclin-dependent kinases (Cdk), cyclins and cyclin-dependent kinase inhibitors (Cdki). We show by western blot analysis, that the ApoG2-induced G1...
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Source: Cancer Weekly (2009-08-04)
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