Breast Cancer

Data on breast cancer reported by researchers at Open University

Published in Cancer Weekly, August 4th, 2009

According to a study from Milton Keynes, the United Kingdom, "The clearance of amyloid beta (A beta) from the brain represents a novel therapeutic target for Alzheimer's disease. Conflicting data exist regarding the contribution of adenosine triphosphate-binding cassette transporters to the clearance of Ab through the blood-brain barrier."

"Therefore, we investigated whether Ab could be a substrate for P-glycoprotein (P-gp) and/or for breast cancer resistance protein (BCRP) using a human brain endothelial cell line, hCMEC/D3. Inhibition of P-gp and BCRP increased apical-to-basolateral, but not basolateral-to-apical, permeability of hCMEC/D3 cells to I-125 A beta 1- 40....

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Source: Cancer Weekly (2009-08-04)

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