Non-Small Cell Lung Cancer

Researchers at Kobe University, International Center for Medical Research target non-small cell lung cancer

Published in Cancer Weekly, August 4th, 2009

Current study results from the report, 'Expression and localization of FOXO1 in non-small cell lung cancer,' have been published. According to a study from Kobe, Japan, "FOXO1 (FKHR), one of the forkhead family of transcription factors, is involved in proapoptotic signaling. Phosphorylated Akt leads to the inhibition of FOXO1 activity by direct phosphorylation and cytoplasmic sequestration."

"We investigated the localization of FOXO1 in non-small cell lung cancer (NSCLC) cell lines grown in a variety of media. FOXO1 expression in tissue microarrays of clinical NSCLC samples was analyzed immunohistochemically. Significant correlations between these data were assessed in...

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Source: Cancer Weekly (2009-08-04)

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