Cancer Vaccines

New findings in cancer vaccines described by D. Peruzzi and co-researchers

Published in Cancer Weekly, August 4th, 2009

According to a study from Pomezia, Italy, "Matrix metalloproteinases (MMP) are zinc-dependent endopeptidases that mediate numerous physiologic and pathologic processes, including matrix degradation, tissue remodeling, inflammation, and tumor metastasis. To develop a vaccine targeting stromal antigens expressed by cancer-associated fibroblasts, we focused on MMP11 (or stromelysin 3)."

"MMP11 expression correlates with aggressive profile and invasiveness of different types of carcinoma. To show the efficacy of a vaccine targeting MMP11, we constructed a series of plasmid DNA vectors expressing murine MMP11. Mice were vaccinated by i.m. injection followed by in vivo DNA...

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Source: Cancer Weekly (2009-08-04)

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