Cancer
New data from M. Verreault et al illuminate research in cancer
Published in Cancer Weekly, August 11th, 2009
"Short interfering RNA targeting ILK ( ILK siRNA) could be used to treat patients with cancers where constitutive activation of the AKT/PI3K pathway is prominent (e.g., those cancers lack functional PTEN). It is generally believed that siRNA therapeutics will require the use of delivery systems and lipid-based formulations containing cationic lipids (CLs) are a viable option," scientists writing in the journal Oligonucleotides report.
"However, CLs are known to be toxic and exposure to CLs can influence cell survival pathways. This study characterized how CLs combine with ILK siRNA to influence the AKT/PI3K pathway. Using PTEN-negative cell lines (PC3...
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Source: Cancer Weekly (2009-08-11)
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