Cancer

Reports summarize cancer study results from University of Hong Kong

Published in Cancer Weekly, August 11th, 2009

"Repulsive guidance molecule member A (RGMA) is a glycosylphosphatidylinositol-anchored glycoprotein and axon guidance molecule char signals through its receptor, neogenin (NEO1), a homologue of the deleted-in-colorectal cancer (DCC) gene. RGMA also functions as a bone morphogenetic protein (BMP) coreceptor," investigators in Hong Kong, People's Republic of China report.

"We studied the potential roles of RGMA and NEO1 in colorecral cancer (CRC) pathogenesis. We analyzed expression of RGMA and NEO1, as well as their epigenetic and generic changes, in a large series of CRC samples, normal colon tissues, adenomas, and cell lines. These studies were accompanied by in vitro...

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Source: Cancer Weekly (2009-08-11)

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