Cancer
Research from National Cancer Institute yields new data on cancer
Published in Cancer Weekly, August 11th, 2009
"Triggering receptor expressed on myeloid cells-like (TREM-like) transcript-1 (TLT-1), a type 1 single Ig domain orphan receptor specific to platelet and megakaryocyte a-granules, relocates to the platelet surface upon platelet stimulation. We found here that patients diagnosed with sepsis, in contrast to healthy individuals, had substantial levels of soluble TLT-1 (sTLT-1) in their plasma that correlated with the presence of disseminated intravascular coagulation. sTLT-1 bound to fibrinogen and augmented platelet aggregation in vitro," scientists writing in the Journal of Clinical Investigation report.
"Furthermore, the cytoplasmic domain of TLT-1 could also...
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Source: Cancer Weekly (2009-08-11)
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