Published in Cancer Weekly, August 11th, 2009
"To further improve the efficacy of DNA-EP, we evaluated small interfering RNA (siRNA) sequences targeting apoptotic genes as an adjuvant to cancer vaccine. Bak1 or Casp8 siRNA was coadministered with plasmid DNA encoding the extracellular and transmembrane domains of rat HER2 ECD. TM to BALB-neuT mice, which spontaneously develop HER2/neu-positive mammary tumors. The combination regimen...
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