Gene Therapy

Study results from F. Gennari and colleagues update understanding of gene therapy

Published in Cancer Weekly, August 11th, 2009

"Lentiviral vectors are promising vaccines because they can transduce and express antigens in dendritic cells in vivo, leading to potent immunization. To improve the safety and efficacy of lentivector vaccination, we sought to target vector transduction to antigen-presenting cells by modifying the viral envelope," scientists writing in the journal Human Gene Therapy report.

"To do this we screened a nonimmunized human single-chain antibody phage display library for phage that bound mouse bone marrow-derived dendritic cells (BMDCs) and isolated three single-chain antibodies (scFvs) that bound to more than 20% of cells in the BMDC culture. The three scFvs also...

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Source: Cancer Weekly (2009-08-11)

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