Fusion Proteins
Research on fusion proteins detailed by scientists at University of California
Published in Cancer Weekly, August 11th, 2009
According to recent research published in the journal Molecular Pharmaceutics, "Matrix attachment therapy (MAT) is an enzyme prodrug strategy that targets hyaluronan in the tumor extracellular matrix to deliver a prodrug converting enzyme near the tumor cells. A recombinant fusion protein containing the hyaluronan binding domain of TSG-6 (Link) and yeast cytosine deaminase (CD) with an N-terminal His(x6) tag was constructed to test MAT on the C26 colon adenocarcinoma in Balb/c mice that were given 5-fluorocytosine (5-FC) in the drinking water."
"LinkCD was expressed in Escherichia coli and purified by metal-chelation affinity chromatography. The purified LinkCD...
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Source: Cancer Weekly (2009-08-11)
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