Glioma

Research from University of Cambridge yields new data on glioma

Published in Cancer Weekly, August 11th, 2009

According to a study from Cambridge, the United Kingdom, "Human brain tumors appear to have a hierarchical cellular organization suggestive of a stern cell foundation. In vitro expansion of the putative cancer stem cells as stable cell lines would provide a powerful model system to study their biology."

"Here, we demonstrate routine and efficient derivation of adherent cell lines from malignant glioma that display stem cell properties and initiate high-grade gliomas following xenotransplantation. Significantly, glioma neural stem (GNS) cell lines from different tumors exhibit divergent gene expression signatures and differentiation behavior that correlate with specific...

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Source: Cancer Weekly (2009-08-11)

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